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Coronary heart disease risk in patients with schizophrenia: a Lebanese cross-sectional study

Chadia Haddad1,2, Souheil Hallit1,3,4,5,2, Pascale Salameh3,6

  • 1Research Department, Psychiatric Hospital of the Cross, Jal Eddib, Lebanon.

Journal of Comorbidity
|November 2, 2017
PubMed

Insights

Coronary heart disease (CHD) risk is significant in Lebanese schizophrenia patients. Metabolic syndrome and longer illness duration increase risk, while certain medications may lower it.

Area of Science:

  • Cardiology
  • Psychiatry
  • Public Health

Background:

  • Coronary heart disease (CHD) is a major cause of early mortality in schizophrenia patients.
  • CHD risk in the Lebanese schizophrenia population is currently unknown.

Purpose of the Study:

  • To assess the 10-year hard CHD risk in Lebanese schizophrenia patients.
  • To identify modifiable and non-modifiable factors influencing CHD risk in this population.

Main Methods:

  • A cross-sectional study involving 329 schizophrenia patients aged 20-75 years.
  • Ten-year hard CHD risk calculated using the Framingham risk score.
  • Logistic regression analysis to determine factors associated with CHD risk.

Main Results:

  • 60.8% of patients had low (<10%), 31.6% intermediate (10-20%), and 7.6% high (>20%) 10-year hard CHD risk.
  • Higher risk observed with metabolic syndrome, longer schizophrenia duration, and co-existing medical illnesses.
  • Certain medications (risperidone, anti-epileptics, benzodiazepines) were associated with lower CHD risk.

Conclusions:

  • Coronary heart disease is prevalent among schizophrenia patients in Lebanon.
  • Monitoring metabolic syndrome components is crucial for identifying high-risk individuals.
  • Targeted interventions are needed to mitigate cardiovascular disease risk in this vulnerable group.
Abstract

Keywords:
Framingham risk scoreantipsychoticscardiovascular diseaselifestyle interventionsschizophrenia

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