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Updated: Feb 19, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Nonsyndromic Multiple Basal Cell Carcinomas
Dong Hwi Kim1, Hyo Sun Ko1, Young Joon Jun1
1Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Multiple basal cell carcinoma (BCC) with parotid invasion is rare. This report details two cases, including a unique instance of parotid invasion linked solely to actinic keratosis, highlighting the importance of early BCC diagnosis and treatment.
Area of Science:
- Dermatology
- Oncology
Background:
- Multiple basal cell carcinoma (BCC) lesions are common, but nonsyndromic BCC with parotid gland invasion is exceptionally rare.
- Actinic keratosis can also present as multiple lesions and may precede or coexist with BCC.
Purpose of the Study:
- To report two rare cases of multiple, sporadic, nonsyndromic basal cell carcinoma.
- To highlight a unique case of parotid invasion associated with actinic keratosis.
Main Methods:
- Surgical excision of multiple skin lesions.
- Pathological examination of excised tissue for diagnosis of basal cell carcinoma and actinic keratosis.
Main Results:
- Case 1: A 79-year-old female with multiple BCC and actinic keratosis, later developing squamous cell carcinoma in situ and actinic keratosis in new lesions.
- Case 2: A 43-year-old female with multiple BCC lesions diagnosed via surgical excision and pathology.
- One presented with parotid invasion linked to actinic keratosis.
Conclusions:
- Multiple basal cell carcinoma, especially with parotid invasion, represents a rare clinical scenario.
- Early diagnosis and treatment of basal cell carcinoma are crucial to prevent disfigurement and destruction, even in non-metastatic cases.
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