Subcutaneous Sarcoidosis Occurring in Both Chin and Toe

Area of Science:

• Dermatology
• Rheumatology
• Pulmonology

Background:

• Sarcoidosis is a systemic inflammatory disease characterized by non-caseating granulomas.
• Subcutaneous sarcoidosis is rare, typically affecting the face or forearms, with toe involvement being exceptionally uncommon.

Purpose of the Study:

• To report an extremely rare case of sarcoidosis presenting with simultaneous subcutaneous masses on the chin and toe.
• To emphasize the diagnostic challenges and the need for thorough investigation in atypical sarcoidosis presentations.

Main Methods:

• Clinical presentation of a 33-year-old male with chin and toe masses.
• Preoperative ultrasonography followed by surgical excision and histopathological examination of the masses.
• Chest computed tomography (CT) for systemic evaluation.

Main Results:

• Histopathology confirmed chronic granulomatous inflammation, consistent with sarcoidosis, in both chin and toe tissues.
• Chest CT revealed characteristic pulmonary nodules and lymphadenopathy, supporting the diagnosis of sarcoidosis.
• The patient was diagnosed with sarcoidosis based on combined histopathological and imaging findings.

Conclusions:

• This case represents a unique presentation of sarcoidosis involving both the face and the foot.
• The findings underscore the necessity of a comprehensive diagnostic workup to identify potential systemic involvement when sarcoidosis is suspected in facial subcutaneous tissue.