[Key physical parameters of hawthorn leaf granules by stepwise regression analysis method]

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Hawthorn leaf extract is a model drug.
• Understanding granule physical properties is crucial for drug dissolution.

Purpose of the Study:

• Investigate the impact of hawthorn leaf granule physical properties on dissolution behavior.
• Identify key physical characteristics influencing drug release.

Main Methods:

• Granules prepared using extrusion and high shear granulation.
• Dissolution evaluated by equilibrium dissolution quantity and rate constant.
• Stepwise regression analysis used to correlate physical properties with dissolution.

Main Results:

• Equilibrium dissolution quantity correlated positively with monolayer adsorption capacity and negatively with moisture absorption rate.
• Dissolution rate constants decreased with increasing Hausner rate, monolayer adsorption capacity, and adsorption heat constant.
• Dissolution rate constants increased with increasing Carr index and specific surface area.

Conclusions:

• Monolayer adsorption capacity, adsorption heat constant, moisture absorption rate, Carr index, and specific surface area are key physical properties affecting hawthorn leaf granule dissolution.
• These findings aid in optimizing hawthorn leaf granule formulation for improved drug delivery.