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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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Related Experiment Video

Updated: Feb 19, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Physical exercise training for cystic fibrosis.

Thomas Radtke¹, Sarah J Nevitt, Helge Hebestreit

¹Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, Zurich, Switzerland, 8001.

The Cochrane Database of Systematic Reviews

|November 2, 2017

Summary

Physical exercise training offers potential benefits for individuals with cystic fibrosis (CF), improving aerobic capacity and quality of life. However, evidence quality is low, necessitating further high-quality trials.

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Area of Science:

Pulmonology
Rehabilitation Medicine
Clinical Exercise Physiology

Background:

Physical exercise training is considered a key component of comprehensive care for cystic fibrosis (CF) patients.
This review is an updated analysis of the existing evidence on exercise interventions in CF.

Purpose of the Study:

To evaluate the impact of physical exercise training on exercise capacity (peak oxygen consumption), pulmonary function (forced expiratory volume in one second), and health-related quality of life in individuals with CF.
To assess other significant patient-relevant outcomes associated with exercise interventions in CF.

Main Methods:

A systematic review of randomized and quasi-randomized controlled trials was conducted.
Searches included the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register and ongoing trials registers.
Fifteen studies involving 487 participants met the inclusion criteria, with variations in study design, participant age, disease severity, and training protocols.

Main Results:

Low- to very low-quality evidence suggests that aerobic, anaerobic, or combined exercise training may positively affect aerobic exercise capacity, pulmonary function, and health-related quality of life in people with CF.
Improvements were inconsistent across studies, with maximal aerobic exercise capacity showing the most consistent positive effects.
Limited evidence exists for effects on pulmonary exacerbations and diabetic control; no studies reported mortality data.

Conclusions:

The current evidence base for exercise training efficacy in CF is limited due to small study sizes and moderate-to-low methodological quality.
While exercise is part of standard CF care with some evidence of benefit and no reported adverse effects, its precise impact is unclear.
High-quality randomized controlled trials are essential to determine the optimal type, duration, and combination of exercise training for individuals with CF.