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Different EGFR gene mutations in two patients with synchronous multiple lung cancers: A case report
Hiroki Sakai1, Hisashi Saji1,2, Hiroyuki Kimura1
1Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
Abstract:
Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma. The present report highlights the clinical importance of molecular cancer biomarkers to guide management decisions in cases involving multiple lung tumors.
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