Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rapid phagosome formation drives parasite control in subclinical <i>Leishmania braziliensis</i> infection.

Frontiers in immunology·2026

Same author

An observational study to test the potency of GLP-grade phenol-free lyophilised leishmanin antigen formulation.

EBioMedicine·2026

Same author

Annexin A1 downregulates <i>in vitro</i> IL-1<i>β</i> production in <i>L. braziliensis</i>-infected cells.

Frontiers in immunology·2025

Same author

Topical AuNPs-Cys-Sm29 gel modulates the course of lesion development in experimental cutaneous leishmaniasis.

PLoS neglected tropical diseases·2025

Same author

Staphylococcus aureus promotes strain-dependent immunopathology during cutaneous leishmaniasis through induction of IL-1β.

Cell reports·2025

Same author

High glucose heightens vulnerability to <i>Leishmania braziliensis</i> infection in human macrophages by hampering the production of reactive oxygen species through TLR2 and TLR4.

Emerging microbes & infections·2025

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

Cytotoxic activity in cutaneous leishmaniasis.

Taís M Campos^1,2, Rúbia Costa^1,2, Sara Passos^1,3

¹Universidade Federal da Bahia, Serviço de Imunologia, Salvador, BA, Brasil.

Memorias Do Instituto Oswaldo Cruz

|November 2, 2017

Summary

Cutaneous leishmaniasis (CL) involves skin ulcers from Leishmania parasites. This review examines how cell cytotoxicity contributes to CL pathogenesis and inflammation.

More Related Videos

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major

Published on: October 28, 2022

Related Experiment Videos

Last Updated: Feb 19, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major

Published on: October 28, 2022

Area of Science:

Immunology
Parasitology
Dermatology

Background:

Cutaneous leishmaniasis (CL) is a chronic skin disease caused by Leishmania parasites.
CL presents with ulcerated skin lesions, influenced by parasite and host factors.
Inflammatory responses, involving cytotoxic cells, play a role in CL pathogenesis.

Purpose of the Study:

To review the role of cytotoxicity in the pathogenesis of cutaneous leishmaniasis.
To explore the contribution of cytotoxic cells, such as CD8+ T cells and natural killer cells, to CL.
To understand how these cellular mechanisms influence disease presentation and progression.

Main Methods:

Literature review focusing on studies of cytotoxicity in CL.
Analysis of research on inflammatory responses and cellular pathogenesis in CL.
Synthesis of findings related to CD8+ T cells and natural killer cell activity in Leishmania infections.

Main Results:

CD8+ T cells contribute to detrimental inflammatory responses in CL via cytotoxic mechanisms.
Natural killer cells limit Leishmania infections through interferon-gamma production and cytotoxicity.
Cytotoxicity is a key factor in the inflammatory process and ulcer development in CL.

Conclusions:

Cytotoxicity mediated by immune cells is a significant contributor to the pathogenesis of cutaneous leishmaniasis.
Understanding the role of cytotoxic mechanisms is crucial for developing effective therapeutic strategies for CL.
Further research into cell-mediated cytotoxicity can elucidate disease progression and host-parasite interactions in CL.