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Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats.

Lubin Huang¹, Kejing Huang², Hong Ning¹

¹Ji'nan Central Hospital Affiliated to Shandong University, Jinan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie

|November 2, 2017

Summary

Hispidulin, a natural compound, protects against sevoflurane-induced memory deficits in aged rats by reducing apoptosis, Aβ accumulation, and neuroinflammation via Nrf2 activation. This suggests hispidulin

Keywords:

Hispidulin Memory dysfunction Nrf2 Sevoflurane

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Published on: July 25, 2025

Area of Science:

Neuroscience
Pharmacology
Gerontology

Background:

Sevoflurane, a common anesthetic, can cause cognitive and memory impairments in the elderly, potentially increasing Alzheimer's disease risk.
Natural compounds are being investigated for neuroprotective properties against anesthetic-induced neurological dysfunction.

Purpose of the Study:

To investigate the neuroprotective effects of hispidulin, a natural flavone, against sevoflurane-induced memory dysfunction in aged rats.
To elucidate the underlying mechanisms, including apoptosis, amyloid-beta (Aβ) accumulation, neuroinflammation, and the role of Nrf2.

Main Methods:

Aged rats were used to assess memory function via novel object recognition and Y-maze tests after sevoflurane exposure.
Apoptosis, Aβ accumulation, and neuroinflammation markers were analyzed in rat hippocampus using TUNEL assay and Western blot.
In vitro studies using human neuroglioma H4 cells examined hispidulin's effects on apoptosis, Aβ, neuroinflammation, and Nrf2 activation.

Main Results:

Sevoflurane significantly impaired memory in aged rats, an effect reversed by hispidulin pretreatment.
Hispidulin attenuated sevoflurane-induced apoptosis, Aβ accumulation, and neuroinflammation both in vivo and in vitro.
Nrf2 activation was identified as a key mediator of hispidulin's neuroprotective effects, as demonstrated by siRNA knockdown experiments.

Conclusions:

Hispidulin demonstrates significant neuroprotective potential against sevoflurane-induced neurological dysfunction.
Hispidulin may improve cognitive and memory function in elderly patients undergoing anesthesia.
The findings support hispidulin as a promising therapeutic agent for preventing anesthetic-related cognitive decline.