Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chromatin-associated intronic RNAs from long genes form introsomes that shape nuclear architecture in neuronal cells.

bioRxiv : the preprint server for biology·2026

Same author

Correction: Annotation of nuclear lncRNAs based on chromatin interactions.

PloS one·2026

Same author

Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues.

Genome biology·2026

Same author

Federated single-cell QTL meta-analysis reveals novel disease mechanisms.

bioRxiv : the preprint server for biology·2026

Same author

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting.

Nature communications·2026

Same author

Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice.

JBMR plus·2026

Same journal

Multi-view knowledge-guided flow subgraphs with substructure initialization for explainable DDI prediction.

Briefings in functional genomics·2026

Same journal

Genetically supported mediators linking peripheral metabolism to cerebral ischemia: a multi-omics characterization of HMGCR, TLR4, and MMP9 in angina pectoris and stroke.

Briefings in functional genomics·2026

Same journal

Language model-based self-training reduces labeled data requirements by 99% for biological sequence classification.

Briefings in functional genomics·2026

Same journal

Whole-transcriptome sequencing reveals hypoxic esophageal squamous cell carcinoma-derived migrasomes driving cancer-associated fibroblast activation.

Briefings in functional genomics·2026

Same journal

An integrative meta-analysis of SARS-CoV-2 RNA-protein interactomes identifies conserved host factors shared with other RNA viruses.

Briefings in functional genomics·2026

Same journal

Retraction and replacement of: An integrated complete-genome sequencing and systems biology approach to predict antimicrobial resistance genes in the virulent bacterial strains of Moraxella catarrhalis.

Briefings in functional genomics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

The Human Cell Atlas: Technical approaches and challenges.

Chung-Chau Hon¹, Jay W Shin¹, Piero Carninci¹

¹RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Kanagawa, Japan.

Briefings in Functional Genomics

|November 2, 2017

Summary

This summary is machine-generated.

The Human Cell Atlas project aims to map every human cell type. This effort will advance fundamental biology and clinical practice by creating comprehensive cellular maps.

More Related Videos

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

Related Experiment Videos

Last Updated: Feb 19, 2026

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

Area of Science:

Human biology
Cellular biology
Genomics

Background:

The Human Cell Atlas is an international consortium.
It aims to create a comprehensive reference map of all human cell types.
Understanding cellular diversity is crucial for biology and medicine.

Purpose of the Study:

To discuss current technical approaches for generating a Human Cell Atlas.
To identify and address the technical challenges in creating comprehensive cellular maps.
To explore the potential impact of the Human Cell Atlas on biology and clinical practice.

Main Methods:

Review of existing and emerging technologies for single-cell analysis.
Discussion of data integration and computational strategies.
Exploration of scalability and standardization in cell atlasing.

Main Results:

Identification of key technical strategies for cell type characterization.
Highlighting significant challenges in data acquisition, processing, and interpretation.
Outlining the potential for transformative insights into human health and disease.

Conclusions:

The Human Cell Atlas project is technically feasible with current approaches.
Overcoming technical hurdles is essential for realizing the full potential of cellular maps.
This resource promises to revolutionize biological research and clinical applications.