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The ageing heart: the systemic and coronary circulation
Shane Nanayakkara1,2,3, Thomas H Marwick2,4, David M Kaye1,2,3
1Heart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Heart (British Cardiac Society)
|November 3, 2017
Summary
Older adults over 60 experience more cardiovascular disease (CVD), but clinical trials often exclude them. Frailty assessment is crucial for effective CVD treatment in this population.
Area of Science:
- Gerontology
- Cardiology
- Clinical Medicine
Background:
- Cardiovascular disease (CVD) predominantly affects individuals over 60.
- Current cardiovascular guidelines have limited evidence for older populations due to trial underrepresentation.
- Aging is associated with increased arterial stiffness, rising blood pressure, and myocardial ischemia, yet older patients receive less guideline-based therapy.
Purpose of the Study:
- To review cardiovascular changes associated with aging.
- To emphasize the role of frailty in the evaluation and treatment of CVD in older adults.
- To highlight the implications of arterial stiffness and myocardial changes in aging cardiovascular systems.
Main Methods:
- Literature appraisal of cardiovascular changes with aging.
- Focus on systemic and coronary circulation.
- Emphasis on frailty assessment and its impact on CVD treatment.
Main Results:
- Older adults face higher risks for CVD, but are undertreated.
- Frailty, indicated by slow gait speed, predicts mortality and adverse outcomes.
- Non-frail older individuals benefit significantly from CVD therapies.
Conclusions:
- There is an urgent need to include frailty assessment in clinical trials for CVD treatments in older adults.
- Aging impacts cardiovascular function, necessitating tailored treatment approaches.
- Optimizing CVD management in older adults requires addressing age-related changes and frailty.
Keywords:
cardiac procedures and therapycardiac risk factors and preventionglobal disease patternsheart diseasemyocardial disease basic scienceMore Related Videos
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