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The ISB Cancer Genomics Cloud: A Flexible Cloud-Based Platform for Cancer Genomics Research
Sheila M Reynolds1, Michael Miller2, Phyliss Lee2
1Institute for Systems Biology, Seattle, Washington. sreynolds@systemsbiology.org ilya.shmulevich@systemsbiology.org.
The ISB Cancer Genomics Cloud (ISB-CGC) provides cloud-based access to cancer genomic data. Researchers can analyze large datasets using diverse tools and methods, facilitating cancer research advancements.
Area of Science:
- Bioinformatics
- Genomics
- Cloud Computing
Background:
- Large-scale cancer genomic datasets require advanced computational infrastructure.
- The National Cancer Institute funded pilot projects to explore cloud-based solutions.
Purpose of the Study:
- To introduce the ISB Cancer Genomics Cloud (ISB-CGC) as a cloud-based platform for cancer data analysis.
- To highlight the ISB-CGC's Data as a Service approach.
Main Methods:
- Utilizing Google Cloud Platform for data storage and analysis.
- Providing access to The Cancer Genome Atlas (TCGA), TARGET, GENCODE, and COSMIC datasets.
- Offering multiple analysis avenues: complex workflows, common programming languages (Python, R, SQL), and an interactive web application.
Main Results:
- The ISB-CGC enables researchers to analyze terabytes of cancer genomic data.
- It supports the development of new analysis methods and the exploration of genomic data.
- An interactive application allows for the creation of synthetic patient cohorts.
Conclusions:
- The ISB-CGC offers a flexible and powerful cloud environment for cancer genomics research.
- It democratizes access to large cancer datasets and advanced analytical tools.
- The platform supports diverse research needs, from data exploration to complex workflow execution.
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