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Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Detailed Structure and Function of Lymph Nodes

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

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Related Experiment Video

Updated: Feb 19, 2026

Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis

Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis

Published on: June 27, 2020

Tissue-Resident Lymphocytes in the Kidney.

Jan-Eric Turner¹, Martina Becker², Hans-Willi Mittrücker³

¹III. Medical Clinic and j.turner@uke.de.

Journal of the American Society of Nephrology : JASN

|November 3, 2017

Summary

Tissue-resident lymphocytes, crucial for immune surveillance in organs like the kidney, are increasingly recognized. This review explores their presence and roles within the kidney.

Keywords:

Immunology and pathology cytokines lymphocytes

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Last Updated: Feb 19, 2026

Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis

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Murine Bilateral Renal Lymphadenectomy

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Published on: December 30, 2025

Area of Science:

Immunology
Renal Physiology

Background:

Nonlymphoid tissues host distinct tissue-resident lymphocyte subsets with limited recirculation.
These lymphocytes are strategically positioned at barrier sites for rapid pathogen response.

Purpose of the Study:

To review advances in understanding tissue-resident lymphocytes.
To examine evidence for these populations in the kidney.
To discuss their physiological and pathological roles in renal function.

Main Methods:

Literature review of immunological and renal research.
Analysis of studies identifying lymphocyte populations in nonlymphoid tissues.
Synthesis of evidence for kidney-resident lymphocytes.

Main Results:

Kidneys contain innate lymphoid cells, NK cells, NKT cells, MAIT cells, and γδ T cells.
A significant portion of kidney-resident CD4+ T cells exhibit tissue-resident markers (e.g., CD69).

Conclusions:

The kidney harbors diverse tissue-resident lymphocyte populations.
These cells likely play critical roles in kidney physiology and disease.