Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

5.0K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.0K
Cell Inclusions01:27

Cell Inclusions

1.2K
Prokaryotic cells possess a variety of inclusions that play crucial roles in nutrient storage, metabolic processes, and environmental adaptation. These structures enable bacteria to thrive under fluctuating environmental conditions by storing essential resources and optimizing their metabolic efficiency.Carbon Storage: Poly-β-Hydroxybutyric Acid and Glycogen GranulesBacteria frequently store excess carbon in specialized granules. Poly-β-hydroxybutyric acid (PHB) granules are lipid...
1.2K
Golgi Apparatus01:09

Golgi Apparatus

22.4K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
22.4K
Golgi Apparatus01:49

Golgi Apparatus

105.1K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
105.1K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.5K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.5K
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

7.5K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlations between intraparenchymal cerebral temperature and peripheral temperature monitoring sites during rewarming after deep hypothermic circulatory arrest on cardiopulmonary bypass.

BMC surgery·2026
Same author

Surgical relevance of a pedicled omental flap for the treatment of a recurrent giant mycotic left ventricular pseudoaneurysm: a case report and review of the literature.

Journal of medical case reports·2026
Same author

Generalized Lotka-Volterra systems with quenched random interactions and saturating nonlinear response.

Physical review. E·2026
Same author

Early impact of CytoSorb® adsorber on proinflammatory cytokine plasmatic levels in a porcine model of refractory cardiogenic shock supported with VA-ECMO.

BMC cardiovascular disorders·2025
Same author

Beyond the numbers: the challenge of FFR-guided strategies in multivessel disease undergoing CABG-think differently.

European heart journal. Case reports·2025
Same author

Multidimensional evaluation of clinical and functional impairment in a large population of patients with Charcot-Marie-Tooth.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2025

Related Experiment Video

Updated: Feb 19, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.6K

Weibel-Palade bodies at a glance.

Jessica J McCormack1, Mafalda Lopes da Silva1, Francesco Ferraro1

  • 1MRC Laboratory of Molecular Cell Biology, University College London, Gower Street, London, WC1E6BT, UK.

Journal of Cell Science
|November 3, 2017
PubMed
Summary

Weibel-Palade bodies (WPBs) are crucial for vascular health, rapidly releasing proteins for hemostasis and inflammation. Their size regulation is key to controlling these functions and exocytosis processes.

Keywords:
EndotheliumOrganelle biogenesisvon Willebrand factor

More Related Videos

Author Spotlight: Advancing Lens Biomechanics Research Through a Novel Protocol for Imaging Complex Interdigitations and Protein Staining
06:08

Author Spotlight: Advancing Lens Biomechanics Research Through a Novel Protocol for Imaging Complex Interdigitations and Protein Staining

Published on: June 9, 2023

2.8K
Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images
14:28

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Published on: July 15, 2020

8.4K

Related Experiment Videos

Last Updated: Feb 19, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.6K
Author Spotlight: Advancing Lens Biomechanics Research Through a Novel Protocol for Imaging Complex Interdigitations and Protein Staining
06:08

Author Spotlight: Advancing Lens Biomechanics Research Through a Novel Protocol for Imaging Complex Interdigitations and Protein Staining

Published on: June 9, 2023

2.8K
Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images
14:28

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Published on: July 15, 2020

8.4K

Area of Science:

  • Cell Biology
  • Vascular Biology
  • Hemostasis

Background:

  • The vascular endothelium must rapidly respond to physiological and pathological changes.
  • Endothelial cells utilize Weibel-Palade bodies (WPBs) for regulated exocytosis of bioactive molecules.
  • WPBs contain proteins critical for hemostasis, inflammation, blood pressure modulation, and angiogenesis.

Purpose of the Study:

  • To explore emerging mechanisms controlling Weibel-Palade body (WPB) size.
  • To investigate how WPB size impacts their role in modulating hemostasis.
  • To outline different modes and polarity of WPB exocytosis.

Main Methods:

  • Review of current literature on WPB biogenesis and exocytosis.
  • Analysis of the role of von Willebrand factor in WPB formation, shape, and size.
  • Discussion of WPB size heterogeneity and its functional implications.

Main Results:

  • WPB size varies significantly, with larger granules being over ten times the size of smaller ones.
  • Von Willebrand factor is the primary driver of WPB formation, dictating their shape and size.
  • Emerging evidence suggests mechanisms controlling WPB size are critical for their function.

Conclusions:

  • WPB size regulation is a key factor in their ability to modulate hemostasis.
  • Understanding WPB biogenesis and exocytosis provides insights into endothelial cell function.
  • These large secretory organelles serve as a model for studying granule biogenesis and exocytosis cooperation.