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A case-control study between the STIM1 gene and hypertensive disorders of pregnancy

Kaori Shinya1, Tomohiro Nakayama2,3, Takuo Nakayama1

  • 1Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|November 3, 2017
PubMed

Insights

Genetic variations in the Stromal Interaction Molecule 1 (STIM1) gene are linked to hypertensive disorders of pregnancy (HDP). Identifying these STIM1 gene SNPs and haplotypes may help predict HDP risk and guide prevention strategies.

Area of Science:

  • Genetics
  • Obstetrics
  • Cardiovascular Medicine

Background:

  • Hypertensive disorders of pregnancy (HDP) represent a significant global health concern, often influenced by multifactorial genetic predispositions.
  • Stromal Interaction Molecule 1 (STIM1) plays a crucial role in regulating intracellular calcium levels and vascular smooth muscle contraction, suggesting its potential involvement in HDP pathogenesis.

Purpose of the Study:

  • To investigate the association between single-nucleotide polymorphisms (SNPs) and haplotypes within the human STIM1 gene and the risk of developing HDP.
  • To identify specific STIM1 genetic markers that may serve as indicators for HDP susceptibility.

Main Methods:

  • A case-control study was conducted involving 139 HDP patients and 162 age-matched controls.
  • Five selected SNPs in the STIM1 gene were genotyped and analyzed for associations with HDP.
  • Statistical analyses, including logistic regression, were employed to evaluate genotype, allele, and haplotype frequencies.

Main Results:

  • Significant associations were observed between specific STIM1 SNPs (rs7945554 and rs10458894) and HDP, including genotype, recessive, dominant, and allele models.
  • Several STIM1 haplotypes (e.g., A-T-G-G, A-C-A-G) showed significant differences between HDP patients and controls.
  • The AA genotype of rs7945554 was found to be more prevalent in the HDP group.

Conclusions:

  • The study identifies specific SNPs and haplotypes in the STIM1 gene as potential genetic markers associated with HDP.
  • The STIM1 gene is implicated as a possible susceptibility gene for hypertensive disorders of pregnancy.
  • These findings could contribute to personalized risk assessment and preventative strategies for HDP by considering genetic predisposition.

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