Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Stability01:53

RNA Stability

35.9K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dorsal Flattening with Periosteal Tensioning: Management of the Central Keystone Blocking Point in Dorsal Preservation Rhinoplasty: A Clinical and Anatomic Study.

Facial plastic surgery : FPS·2026
Same author

Argonautes and small RNAs associated with nematode programmed DNA elimination.

bioRxiv : the preprint server for biology·2025
Same author

Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of <i>Drosophila melanogaster</i>.

Evolution letters·2025
Same author

Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource.

Molecular biology and evolution·2025
Same author

XBB.1.5 mRNA COVID-19 vaccine protection against inpatient or emergency department visits among adults infected with SARS-CoV-2 JN.1 and XBB-lineage variants.

Frontiers in immunology·2025
Same author

Reduced Likelihood of Hospitalization With the JN.1 or HV.1 Severe Acute Respiratory Syndrome Coronavirus 2 Variants Compared With the EG.5 Variant.

The Journal of infectious diseases·2024

Related Experiment Video

Updated: Feb 19, 2026

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K

Double Stranded RNA in Human Seminal Plasma.

Maxim V Zagoskin1,2, Richard E Davis2, Dmitry V Mukha1

  • 1Laboratory of Genetic Basis of Biodiversity, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.

Frontiers in Genetics
|November 3, 2017
PubMed
Summary
This summary is machine-generated.

Human seminal plasma contains double-stranded RNA (dsRNA), which may influence offspring and serve as biomarkers. This study details methods for isolating dsRNA and explores its potential roles in gene regulation and inheritance.

Keywords:
double stranded RNAgenetic molecular markershuman seminal plasmaphenotype of offspringtelegony

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K
Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification
04:43

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification

Published on: October 11, 2024

2.5K

Related Experiment Videos

Last Updated: Feb 19, 2026

Isolation of Small Noncoding RNAs from Human Serum
06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.3K
Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification
04:43

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification

Published on: October 11, 2024

2.5K

Area of Science:

  • Reproductive biology
  • Molecular biology
  • Genetics

Background:

  • Human semen contains various cell-free nucleic acids, including DNA and RNA.
  • RNAs in semen are hypothesized to mediate intercellular communication and regulate gene expression in the male reproductive system.

Purpose of the Study:

  • To demonstrate the presence of cell-free double-stranded RNA (dsRNA) in human seminal plasma.
  • To establish a method for isolating dsRNA from seminal plasma.
  • To explore the potential biological roles of dsRNA in inheritance and gene regulation.

Main Methods:

  • Isolation of cell-free nucleic acids from human seminal plasma.
  • Characterization of double-stranded RNA (dsRNA) present in the seminal plasma.
  • Development of a preparative method for dsRNA isolation.

Main Results:

  • Confirmation of diverse cell-free dsRNAs within human seminal plasma.
  • Establishment of a robust protocol for isolating dsRNA in significant quantities.
  • Identification of dsRNA's stability and cell-penetrating capabilities.

Conclusions:

  • Cell-free dsRNA in seminal plasma may influence human oocytes and consequently, the offspring.
  • dsRNA could play a role in regulating gene expression and inheritance.
  • Seminal dsRNAs may serve as potential biomarkers for studying human physiopathological conditions and genetic variations.