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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Resolving the clinico-radiological paradox in multiple sclerosis.

Declan Chard1,2, S Anand Trip1,2

  • 1National Institute for Health Research (NIHR) University College London Hospitals (UCLH), Biomedical Research Centre, London, UK.

F1000Research
|November 3, 2017
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Summary

The clinico-radiological paradox in multiple sclerosis (MS) impacts treatment decisions. Understanding this disconnect aids in developing better markers for relapses and disability progression in MS patients.

Keywords:
MRIclinico-radiological paradoxmultiple sclerosis

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Area of Science:

  • Neurology
  • Radiology
  • Clinical Research

Background:

  • The clinico-radiological paradox in multiple sclerosis (MS) refers to discrepancies between clinical symptoms and MRI findings.
  • This paradox complicates treatment choices and understanding disease pathophysiology.

Purpose of the Study:

  • To review the underlying themes and issues of the clinico-radiological paradox in MS.
  • To discuss recent advances in resolving this paradox for improved patient management.

Main Methods:

  • Literature review of existing studies on the clinico-radiological paradox in multiple sclerosis.
  • Analysis of recent research focusing on surrogate markers and pathophysiological insights.

Main Results:

  • The paradox highlights the need for better surrogates for relapse and disability progression in MS.
  • Advances are being made in understanding the relationship between imaging and clinical outcomes.

Conclusions:

  • Resolving the clinico-radiological paradox is crucial for personalized treatment strategies in MS.
  • Further research is needed to identify and validate reliable surrogates for MS progression.