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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammation01:38

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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Inflammation, ageing, and bone regeneration.

Emmanuel Gibon1, Laura Y Lu1, Karthik Nathan1

  • 1Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.

Journal of Orthopaedic Translation
|November 3, 2017
PubMed
Summary
This summary is machine-generated.

Bone healing involves complex cell interactions and inflammation. Aging increases inflammation, potentially hindering bone regeneration and osteogenesis, impacting healing outcomes.

Keywords:
ageingboneinflammationmacrophagesstem cells

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Area of Science:

  • Bone biology and regenerative medicine
  • Immunology and aging research

Background:

  • Bone healing is a complex biological process involving cellular interactions and microenvironments.
  • The monocyte-macrophage-osteoclast and mesenchymal stem cell-osteoblast lineages are crucial for bone regeneration.
  • Aging is associated with increased basal inflammation, which may negatively affect bone healing.

Purpose of the Study:

  • To review recent findings on the effects of inflammation and aging on bone healing.
  • To highlight the translational potential of understanding these interactions.

Main Methods:

  • Literature review of translational research on inflammation, aging, and bone regeneration.
  • Synthesis of current knowledge on cellular mechanisms in bone healing.

Main Results:

  • Inflammation and aging significantly interact and influence bone regeneration processes.
  • Specific cellular lineages and inflammatory milieu are critical for effective bone healing.
  • Age-related inflammation may impair the osteogenic capacity of cells involved in bone repair.

Conclusions:

  • Understanding the interplay between inflammation, aging, and bone healing is vital for developing therapeutic strategies.
  • Targeting inflammatory pathways could enhance bone regeneration in aging populations.
  • Further research is needed to elucidate the precise mechanisms by which aging impacts bone healing.