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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
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Related Experiment Video

Updated: Feb 19, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

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Host-Directed Therapeutic Strategies for Tuberculosis.

Afsal Kolloli1, Selvakumar Subbian1

  • 1Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers Biomedical and Health Sciences (RBHS), Rutgers University, The State University of New Jersey, Newark, NJ, United States.

Frontiers in Medicine
|November 3, 2017
PubMed
Summary

Host-directed therapy (HDT) offers a novel approach to tuberculosis treatment by modulating host responses. This strategy, used alongside antibiotics, shows potential for improving outcomes and shortening treatment duration for drug-resistant tuberculosis.

Keywords:
adjunct therapy-tuberculosisanti-tuberculosis drugsautophagyhost–pathogen interactionsinfanttuberculosisvitamin D

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Pharmacology

Background:

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a major global health challenge.
  • Standard antibiotic treatment is lengthy, leading to non-compliance and drug-resistant strains (MDR and XDR-TB).
  • Comorbidities like HIV complicate treatment and increase mortality.

Purpose of the Study:

  • To review recent findings on small molecule host-directed therapy (HDT) agents for TB treatment.
  • To explore HDT's potential as an adjunctive therapy to standard antibiotics.
  • To assess HDT's role in managing drug-resistant TB and TB in patients with comorbidities.

Main Methods:

  • Review of recent publications on small molecule HDT agents.
  • Focus on agents targeting autophagy, vitamin D pathway, and anti-inflammatory responses.
  • Analysis of HDT as an adjunct to standard antibiotic therapy for TB.

Main Results:

  • HDT agents modulate host cell functions, avoiding Mtb drug resistance.
  • HDT can fine-tune immune cell activity and reduce TB-associated inflammation and tissue damage.
  • Current evidence suggests HDT is most effective as an adjunct to antibiotics, not as a standalone treatment.

Conclusions:

  • Host-directed therapy is a promising strategy for improving TB treatment outcomes.
  • HDT, particularly when used with standard antibiotics, may reduce treatment duration and enhance global TB control.
  • Further clinical evidence is needed to establish HDT as a standalone therapy.