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Hydrogel/fiber conductive scaffold for bone tissue engineering.
Sajedeh Khorshidi1, Akbar Karkhaneh1
1Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Journal of Biomedical Materials Research. Part A
|November 3, 2017
Summary
This study developed electrically conductive hydrogel/fiber scaffolds for bone regeneration. The composite material enhanced cell growth and shows promise for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Hydrogel/fiber composites are promising scaffolds for tissue regeneration.
- Biorelated modifications can enhance the regenerative functionality of these composites.
Purpose of the Study:
- To prepare and evaluate an electrically conductive hydrogel/fiber scaffold.
- To investigate the scaffold's potential for bone regeneration.
Main Methods:
- Polyaniline (PANi)-based fibers were fabricated using electrospinning and 3D structuring via ultrasonication.
- A hydrogel precursor solution containing oxidized polysaccharides, gelatin, and graphene nanoparticles was combined with the fibers.
- The composite scaffold's physical, mechanical, and biological properties were assessed.
Main Results:
- The hydrogel/fiber composite exhibited increased elastic modulus, roughness, and electrical conductivity compared to the pristine hydrogel.
- Hydrophilicity was decreased in the composite material.
- The composite scaffold demonstrated superior support for human osteoblast-like cell adhesion, proliferation, and morphology.
Conclusions:
- The electrically conductive hydrogel/fiber scaffold shows significant potential for bone regeneration applications.
- The combination of gel/fiber architecture and electrical conductivity is key to its promising regenerative capabilities.
