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The plan of enrichment designs for dealing with high placebo response
Xiangmin Zhang1, Yeh-Fong Chen2, Roy Tamura3
1The University of Iowa, Iowa City, IA, USA.
Abstract:
To deal with high placebo response in clinical trials for psychiatric and other diseases, different enrichment designs, such as the sequential parallel design, two-way enriched design, and sequential enriched design, have been proposed and implemented recently. Depending on the historical trial information and the trial sponsors' resources, detailed design elements are needed for determining which design to adopt. To assist in making more suitable decisions, we perform evaluations for selecting required design elements in terms of power optimization and sample size planning. We also discuss the implementation of the interim analysis related to its applicability.
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