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Related Concept Videos

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Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains.

R Blakey1, S Ranlund1, E Zartaloudi1

  • 1Division of Psychiatry,University College London,London,UK.

Psychological Medicine
|November 3, 2017
PubMed
Summary

Psychosis endophenotypes, including cognition and electrophysiology, show consistent interrelationships across individuals with psychotic disorders, unaffected relatives, and healthy controls. These findings support a continuum of psychosis liability in the general population.

Keywords:
Lateral ventricular volumeP300schizophreniaunaffected relativesverbal memoryworking memory

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Psychosis is characterized by various endophenotypes, but their interrelationships remain underexplored.
  • Understanding these connections is crucial for elucidating the underlying mechanisms of psychosis liability.

Purpose of the Study:

  • To investigate the interrelationships between cognitive, electrophysiological, and neuroanatomical endophenotypes in psychosis.
  • To determine if these relationships differ across individuals with psychotic disorders, unaffected relatives, and healthy controls.

Main Methods:

  • A multi-center study involving 8754 participants: 2212 with psychotic disorders, 1487 unaffected relatives, and 5055 healthy controls.
  • Assessment of cognition (digit span, block design, Rey Auditory Verbal Learning Test), electrophysiology (P300 amplitude and latency), and neuroanatomy (lateral ventricular volume).
  • Linear regression analysis was employed to examine the associations between endophenotypes.

Main Results:

  • P300 amplitude and latency were found to be independent endophenotypes.
  • P300 amplitude was positively associated with block design performance.
  • All cognitive endophenotypes demonstrated expected interrelationships (p < 0.001).

Conclusions:

  • P300 amplitude and latency represent distinct endophenotypes, potentially indexing spatial visualization/working memory and processing speed, respectively.
  • Consistent patterns of endophenotype associations were observed across all participant groups.
  • Findings support a continuum of psychosis liability across the population.