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Updated: Feb 19, 2026

Decellularization and Recellularization Methodology for Human Saphenous Veins
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Human Umbilical Vessels: Choosing the Optimal Decellularization Method.

Victor E Rodríguez-Rodríguez1, Brenda Martínez-González, Alejandro Quiroga-Garza

  • 1From the Human Anatomy Department, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey N.L., Mexico.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|November 3, 2017
PubMed
Summary

Human umbilical vessels are a promising source for creating small-diameter vascular grafts. Decellularization techniques using detergents show potential, but further research is needed for optimal scaffold development.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Vascular Surgery

Background:

  • Small-diameter vascular grafts are crucial for treating circulatory diseases.
  • Decellularization of human blood vessels offers a scaffold for creating artificial grafts.
  • Human umbilical vessels are readily available and possess suitable characteristics for graft development.

Purpose of the Study:

  • To review and analyze the morphological and biomechanical properties of decellularized human umbilical arteries and veins.
  • To compare the effectiveness of various decellularization techniques for umbilical vessels.
  • To assess the potential of decellularized umbilical vessels as scaffolds for vascular grafts.

Main Methods:

  • Systematic review of existing literature on decellularization techniques for human umbilical vessels.
  • Analysis of studies reporting morphological and biomechanical assessments of decellularized umbilical vessels.
  • Evaluation of reported extracellular matrix components and recellularization capacities.

Main Results:

  • Decellularization is a viable method for preparing human umbilical vessels as vascular graft scaffolds.
  • Detergents are the most frequently employed and well-documented agents for decellularization.
  • Morphological and biomechanical characteristics vary depending on the decellularization technique used.

Conclusions:

  • Decellularized human umbilical vessels represent a viable option for developing small-diameter vascular grafts.
  • Further investigation into extracellular matrix composition, biomechanical properties, and in vivo functionality is essential.
  • Standardization of decellularization techniques is needed to optimize graft performance.