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Circular RNA profile of infantile hemangioma by microarray analysis
Cong Fu1, Renrong Lv1, Guangqi Xu1
1Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Plos One
|November 3, 2017
Summary
This study profiles circular RNAs (circRNAs) in infantile hemangioma (IH), identifying differentially expressed circRNAs and potential regulatory networks. These findings offer new insights into the molecular mechanisms underlying IH development.
Area of Science:
- Molecular Biology
- Genomics
- RNA Biology
Background:
- Circular RNAs (circRNAs) are emerging as key regulators in various physiological processes.
- The role of circRNAs in infantile hemangioma (IH) pathogenesis is currently unknown.
Purpose of the Study:
- To investigate the expression profile of circRNAs in infantile hemangioma (IH).
- To construct circRNA-microRNA (miRNA)-mRNA networks and explore their potential roles in IH.
Main Methods:
- circRNA expression profiling using microarray analysis in IH and adjacent skin tissues.
- Validation of key circRNAs by quantitative reverse transcription polymerase chain reaction (qRT-PCR).
- Bioinformatic construction of circRNA-miRNA-mRNA regulatory networks.
Main Results:
- Identification of 234 upregulated and 374 downregulated circRNAs in IH tissues.
- Validation of three differentially expressed circRNAs (hsa_circRNA_100933, hsa_circRNA_100709, hsa_circRNA_104310).
- Construction of two circRNA-miRNA-mRNA networks implicated in angiogenesis and vascular development.
Conclusions:
- This study provides the first comprehensive circRNA expression profile in infantile hemangioma.
- The identified circRNAs and networks represent potential therapeutic targets for IH.
- Further research into circRNA functions can elucidate their role in IH pathogenesis.
