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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Related Experiment Video

Updated: Feb 19, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
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Published on: August 15, 2025

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Failed epilepsy surgery deserves a second chance.

Chrystal M Reed1, Sandra Dewar2, Itzhak Fried3

  • 1Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, United States.

Clinical Neurology and Neurosurgery
|November 3, 2017
PubMed
Summary
This summary is machine-generated.

Repeat epilepsy surgery can be successful for patients with intractable seizures. Reoperation, particularly for incomplete resections or tumor recurrence, offers a chance for seizure freedom (Engel Class I) in over half of cases.

Keywords:
Epilepsy surgeryFailed epilepsy surgeryRepeat epilepsy surgery

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Area of Science:

  • Neurosurgery
  • Epileptology
  • Neurology

Background:

  • Resective epilepsy surgery achieves 70-80% success but 20-30% require reoperation.
  • Common failure reasons include incomplete resection, misidentified focus, or tumor recurrence.

Purpose of the Study:

  • To evaluate the outcomes of reoperation in patients with intractable epilepsy.
  • To assess the safety and efficacy of repeat epilepsy surgery.

Main Methods:

  • Retrospective chart review of 17 adult epilepsy patients undergoing reoperation (2007-2014).
  • Utilized high-resolution Brain MRI, FDG-PET, and neuropsychometric testing.
  • Outcomes assessed via prospective follow-up and electronic medical records, classified by modified Engel scale (I-II good).

Main Results:

  • 17 patients (10 female, average age 42) underwent reoperation.
  • Reasons for reoperation: incomplete resection (13), tumor recurrence (4).
  • 58.8% (10/17) achieved seizure freedom (Engel Class I) after second surgery.

Conclusions:

  • Repeat epilepsy surgery is justified due to low complication risk and potential for excellent outcomes.
  • Reoperation can provide seizure freedom for patients with intractable epilepsy, especially after incomplete first resections.