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Updated: Feb 19, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis

Published on: January 7, 2019

Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide.

Michiyo Tsuru¹, Michio Sata², Maki Tanaka³

¹Clinical Proteomics and Gene Therapy Laboratory, Kurume University, Kurume, Japan; Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Japan.

Translational Oncology

|November 3, 2017

Summary

This summary is machine-generated.

A novel RGD peptide in patient sera may predict cancer metastasis years after remission. This biomarker could enable early detection and new treatments for metastatic liver cancer.

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Experimental Metastasis Assay

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Published on: August 24, 2010

Area of Science:

Oncology
Biochemistry
Molecular Biology

Background:

Liver cancer patients achieving remission can still develop metastases years later.
Identifying biomarkers for early metastasis detection is crucial for patient outcomes.

Purpose of the Study:

To identify serum biomarkers for early detection of bone metastases in liver cancer patients.
To investigate a novel RGD-containing peptide's role in cancer metastasis and its therapeutic potential.

Main Methods:

Retrospective analysis of blood sera from 30 liver cancer patients with bone metastases.
Detection and characterization of a novel RGD-containing peptide from fibrinogen.
In vitro studies on epithelial-mesenchymal transition (EMT) and angiogenesis (vascular endothelial growth factor).

Main Results:

A novel RGD-containing peptide was identified in the sera of metastatic liver cancer patients.
This peptide appears to regulate cancer cell EMT, potentially involving miR-199a-3p.
The RGD peptide promoted angiogenesis and increased vascular endothelial growth factor in experimental models.

Conclusions:

The novel RGD peptide serves as a potential early biomarker for detecting cancer metastasis.
This peptide holds promise for developing new therapeutic strategies against metastatic cancer.