Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

338
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
338
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.7K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.7K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

289
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
289
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

258
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
258
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.3K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.3K
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

1.1K
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Women's experiences of discussing health behaviours within their maternity care: a systematic review and meta-synthesis.

Reproductive health·2026
Same author

Social connectedness and disconnectedness in individuals with recent onset psychosis and suicidal experiences: a systematic review of the evidence.

BMC psychiatry·2026
Same author

Women's Experiences of Screening and Assessment of Mental Health Problems in the Perinatal Period: A Systematic Review and Meta-synthesis.

Clinical child and family psychology review·2026
Same author

Household income and adverse childhood outcomes after prenatal myelomeningocele repair.

American journal of obstetrics & gynecology MFM·2026
Same author

The role of anxiety in the relationships between psychotic experiences and suicidal ideation severity.

Journal of affective disorders·2026
Same author

Acute Toxicities During Proton Therapy with or Without Simultaneous Chemotherapy in Pediatric CNS Tumors: A Retrospective Cohort Study.

Cancers·2026

Related Experiment Video

Updated: Feb 19, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.1K

Neurodevelopmental Disorders in the PICU Population.

Sarah A Sobotka1, Sarah Peters1, Neethi P Pinto1

  • 11 University of Chicago, Chicago, IL, USA.

Clinical Pediatrics
|November 4, 2017
PubMed
Summary

Children in the pediatric intensive care unit (PICU) have a high rate of undiagnosed neurodevelopmental disorders, including attention deficit hyperactivity disorder (ADHD). Early identification and support are crucial for this vulnerable population.

Keywords:
ADHDPICU follow-upbehavioral disordersdevelopmental disorderspediatric critical illness

More Related Videos

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

7.5K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.6K

Related Experiment Videos

Last Updated: Feb 19, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.1K
A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
11:27

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn

Published on: April 7, 2023

7.5K
A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

25.6K

Area of Science:

  • Pediatric critical care medicine
  • Neurodevelopmental disorders
  • Child psychology

Background:

  • Attention deficit hyperactivity disorder (ADHD) affects 11% of children and adolescents, increasing risks for injury and illness.
  • The prevalence of ADHD and other developmental disorders in pediatric intensive care units (PICUs) remains understudied.
  • Children with neurodevelopmental disorders may be more susceptible to the impacts of critical illness.

Purpose of the Study:

  • To investigate the prevalence of ADHD and other neurodevelopmental disorders in children admitted to a PICU.
  • To understand the baseline neurodevelopmental status of critically ill children.
  • To inform future support strategies for this population.

Main Methods:

  • A single-center, prospective cohort study was conducted.
  • Children aged 6 to 12 years hospitalized in the PICU were enrolled.
  • Parental interviews regarding neurodevelopmental history and validated ADHD/behavioral disorder screening tools were used.

Main Results:

  • Twenty-four children were enrolled in the study.
  • Ten patients (42%) had a pre-existing neurodevelopmental diagnosis.
  • Seven patients (29%) met the study criteria for ADHD at enrollment.

Conclusions:

  • Critically ill children in the PICU exhibit a high prevalence of neurodevelopmental disabilities.
  • These children are at increased risk for adverse developmental and behavioral outcomes following critical illness.
  • Further research is essential to develop targeted interventions for this vulnerable group.