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Immunophenotyping: Application to Safety Assessment.

Xiaoting Wang1, Hervé Lebrec1

  • 11 Comparative Biology and Safety Sciences, Amgen, Inc., South San Francisco, California, USA.

Toxicologic Pathology
|November 4, 2017
PubMed
Summary
This summary is machine-generated.

Immunophenotyping using clusters of differentiation (CDs) helps identify cell subsets for pharmaceutical safety assessment. This approach is crucial for understanding drug-induced immune responses across species.

Keywords:
clusters of differentiation (CDs)flow cytometryimmunofluorescence (IF)immunohistochemistry (IHC)immunophenotype

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Area of Science:

  • Toxicology
  • Immunology
  • Pharmaceutical Development

Background:

  • Continuing education courses are vital for disseminating specialized knowledge.
  • Immunotoxicology is a critical component of pharmaceutical safety assessment.
  • Immunophenotyping is a key technique in understanding immune cell function.

Purpose of the Study:

  • To summarize key concepts of immunophenotyping presented at the Society of Toxicologic Pathology symposium.
  • To highlight the application of immunophenotyping in pharmaceutical development and safety assessment.
  • To provide an overview of study design considerations for immunophenotyping.

Main Methods:

  • Utilizing clusters of differentiation (CDs) as well-defined cell surface antigens.
  • Characterizing lymphocyte subsets in humans and various animal models.
  • Detecting combinations of CDs to define specific cell populations.

Main Results:

  • Clusters of differentiation (CDs) serve as reliable markers for cell subset identification.
  • Lymphocyte subsets can be effectively defined across species using CD markers.
  • Immunophenotyping provides valuable data for safety assessment.

Conclusions:

  • Immunophenotyping is an essential tool in pharmaceutical development.
  • Understanding cell subsets through CDs aids in evaluating drug safety.
  • Standardized approaches to immunophenotyping enhance toxicological assessments.