Related Experiment Video
Updated: Feb 19, 2026
09:36
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
30.3K
Pregnancy and Breast Cancer
Ramadevi Subramani1, Rajkumar Lakshmanaswamy2
1Center of Emphasis in Cancer Research, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, United States.
Progress in Molecular Biology and Translational Science
|November 4, 2017
Summary
Early full-term pregnancy significantly reduces breast cancer risk, while later pregnancies increase it. This study explores protective mechanisms to develop new prevention and treatment strategies for breast cancer.
Area of Science:
- Oncology
- Reproductive Health
- Cancer Etiology
Background:
- Breast cancer is the most common cancer in women globally.
- The etiology of sporadic breast cancer is not fully understood.
- Pregnancy is a key factor influencing breast cancer risk.
Purpose of the Study:
- To discuss breast cancer types, stages, and risk factors.
- To explore mechanisms of early full-term pregnancy-induced protection.
- To aid in developing novel preventive and therapeutic strategies for breast cancer.
Main Methods:
- Review of epidemiological data.
- Analysis of experimental findings.
- Discussion of potential protective mechanisms.
Main Results:
- Early full-term pregnancy reduces lifetime breast cancer risk.
- Late first full-term pregnancy increases breast cancer risk.
- Abortions do not significantly alter breast cancer risk.
Conclusions:
- Understanding early pregnancy's protective effects can guide breast cancer prevention.
- Identifying these mechanisms may lead to new therapeutic strategies.
- This knowledge can facilitate the development of breast cancer risk biomarkers.
More Related Videos
Related Concept Videos
02:59Cancer Prevention
8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.2K
01:24Disorders of the Female Reproductive System
4.6K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.6K
01:19Psychoneuroimmunology: Diabetes and Cancer
523
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
523
02:07Tumor Progression
7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
01:07Teratogenicity
4.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.3K
02:18Cancer
54.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.7K