Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase.

Journal of industrial microbiology & biotechnology·2015

Same author

Cyclic di-AMP mediates biofilm formation.

Molecular microbiology·2015

Same author

[A review on the epidemiology of Middle East Respiratory Syndrome].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2015

Same author

Fast lithium-ionic conduction in a new complex hydride-sulphide crystalline phase.

Chemical communications (Cambridge, England)·2015

Same author

Platinized Graphene/ceramics Nano-sandwiched Architectures and Electrodes with Outstanding Performance for PEM Fuel Cells.

Scientific reports·2015

Same author

Antiperovskite Chalco-Halides Ba3(FeS4)Cl, Ba3(FeS4)Br, and Ba3(FeSe4)Br with Spin Super-Super Exchange.

Scientific reports·2015

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Published on: December 1, 2014

Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.

William H Bowen¹, Robert A Burne², Hui Wu³

¹Center for Oral Biology, Department of Microbiology & Immunology and Environmental Medicine, University of Rochester Medical Center, Rochester, New York, NY, USA; Deceased (15 November 2016).

Trends in Microbiology

|November 4, 2017

Summary

This summary is machine-generated.

Dental caries, a biofilm disease, is driven by sugars fueling pathogen growth and matrix assembly. Understanding these microbial interactions is key to preventing tooth decay and other biofilm-related infections.

More Related Videos

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Methods for Characterizing the Co-development of Biofilm and Habitat Heterogeneity

Methods for Characterizing the Co-development of Biofilm and Habitat Heterogeneity

Published on: March 11, 2015

Related Experiment Videos

Last Updated: Feb 19, 2026

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Published on: December 1, 2014

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Methods for Characterizing the Co-development of Biofilm and Habitat Heterogeneity

Methods for Characterizing the Co-development of Biofilm and Habitat Heterogeneity

Published on: March 11, 2015

Area of Science:

Microbiology
Oral Health
Infectious Diseases

Background:

Biofilms are organized microbial communities within an extracellular matrix, causing persistent human infections.
Dental caries (tooth decay) is a complex biofilm disease influenced by diet and microbial interactions on tooth surfaces.

Purpose of the Study:

To review recent advances in understanding the role of biofilm matrix and microbial interactions in dental caries pathogenesis.
To highlight the significance of matrix-producing organisms in creating pathogenic environments for polymicrobial infections.

Main Methods:

Literature review of recent research on dental caries biofilms.
Analysis of the role of diet, microbiota-matrix interactions, and interspecies dynamics in disease progression.

Main Results:

Sugars promote pathogen emergence, matrix formation, and acidification within the dental biofilm.
Matrix-producing organisms foster pathogenic habitats, driving disease through interspecies competition and synergy.

Conclusions:

The biofilm matrix and interspecies interactions are critical drivers of dental caries.
Insights into dental caries biofilms may inform strategies against other polymicrobial biofilm infections.