Related Experiment Video
Updated: Feb 19, 2026
09:50
Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
9.9K
Apigenin: A dietary flavonoid with diverse anticancer properties
Josip Madunić1, Ivana Vrhovac Madunić2, Goran Gajski3
1Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000, Zagreb, Croatia.
Cancer Letters
|November 4, 2017
Summary
Apigenin, a plant flavonoid, shows promising anticancer potential with low toxicity. Further research is needed to confirm its effectiveness in cancer treatment.
Area of Science:
- Phytochemistry
- Pharmacology
- Oncology
Background:
- Apigenin is a natural flavonoid abundant in fruits and vegetables.
- It exhibits antioxidant, anti-inflammatory, and anticancer properties.
- Apigenin is recognized for its low toxicity and selective action on cancer cells.
Purpose of the Study:
- To review the role of apigenin in anticancer research.
- To explore its impact on key cancer signaling pathways.
- To assess its potential as a chemotherapeutic agent.
Main Methods:
- Literature review of existing studies on apigenin and cancer.
- Analysis of apigenin's effects on MAPK, PI3K/Akt, and NF-κB pathways.
- Examination of apigenin's role in various cancer types.
Main Results:
- Apigenin demonstrates significant potential in anticancer research.
- It influences critical cancer signaling pathways.
- Apigenin shows differential effects on normal versus cancerous cells.
Conclusions:
- Apigenin is a promising candidate for future anticancer therapies.
- Further in vitro and in vivo studies are essential for clinical translation.
- Apigenin's therapeutic potential warrants continued investigation.
Related Concept Videos
02:59Cancer Prevention
8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.2K
02:38Mitogens and the Cell Cycle
8.2K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.2K
02:34Inhibition of Cdk Activity
6.1K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.1K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
02:50Combination Therapies and Personalized Medicine
6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
24
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
24