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Mitomycin C analogues with a substituted hydrazine at position 7. Synthesis, spectral properties, and biological
1Department of Chemistry, University of Houston, Texas 77204-5641.
Journal of Medicinal Chemistry
|January 1, 1989
Abstract:
A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparable to that of mitomycin C. The X-ray-determined crystal structure of one of the derivatives (3f) is reported.