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Related Experiment Video

Updated: Feb 19, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
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Optimizing Image Quantification for 177Lu SPECT/CT Based on a 3D Printed 2-Compartment Kidney Phantom.

Johannes Tran-Gia1, Michael Lassmann2

  • 1Department of Nuclear Medicine, University of Würzburg, Würzburg, Germany tran_j@ukw.de.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|November 4, 2017
PubMed
Summary

This study optimized activity determination for 177Lutetium (Lu)-based SPECT/CT imaging. The best results were achieved with unsmoothed reconstruction and a recovery coefficient derived from low-dose CT scans, improving accuracy for medical imaging.

Keywords:
2-compartment kidney phantom3D printingpartial volume correctionquantitative SPECT/CTradionuclide therapyxSPECT Quant

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiopharmaceutical Therapy

Background:

  • Accurate activity determination is crucial for quantitative SPECT/CT imaging, especially for radioligand therapies using Lutetium-177 (177Lu).
  • Standard partial-volume correction (PVC) methods may not adequately account for complex geometries, impacting quantification accuracy.

Purpose of the Study:

  • To identify an optimal setup for 177Lu activity determination in SPECT/CT imaging.
  • To evaluate the performance of two commercial reconstruction methods (xSPECT Quant and Flash3D) with various PVC strategies.

Main Methods:

  • 3D-printed phantoms (kidney, sphere, ellipsoid) were used to simulate different geometries.
  • Multiple PVC methods were tested, including geometry-specific recovery coefficients (model-based and CT-based), enlarged volumes, peak-milliliter, and fixed thresholds.
  • The influence of postreconstruction Gaussian filtering was also investigated.

Main Results:

  • Geometry-specific recovery coefficients, particularly those based on low-dose CT, yielded the highest accuracy without postfiltering.
  • Significant differences in recovery coefficients were observed between spherical and renal phantom geometries.
  • Postfiltering generally increased quantification errors across all tested methods.

Conclusions:

  • 3D printing facilitates geometry-specific evaluation of SPECT/CT reconstruction and PVC parameters.
  • An optimal setup involves unsmoothed reconstruction with a CT-based recovery coefficient for accurate 177Lu activity determination.
  • Sphere-based recovery coefficient lookup tables are insufficient; geometry-specific alternatives are recommended.