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Related Concept Videos

Chirality02:25

Chirality

30.0K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
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Chirality in Nature02:30

Chirality in Nature

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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Prochirality02:05

Prochirality

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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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Fischer Projections02:18

Fischer Projections

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Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
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Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
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Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

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Self-assembled three-dimensional chiral colloidal architecture.

Matan Yah Ben Zion1, Xiaojin He2, Corinna C Maass2,3

  • 1Department of Physics, New York University, New York, NY 10003, USA. matanbz@nyu.edu chaikin@nyu.edu.

Science (New York, N.Y.)
|November 4, 2017
PubMed
Summary
This summary is machine-generated.

Researchers programmed micron-sized colloidal clusters to self-assemble with nanoscale structural information. This breakthrough combines DNA nanotechnology and colloidal science, enabling precise control over microconstruct geometry and chirality.

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Synthesis and Characterization of Supramolecular Colloids
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Synthesis and Characterization of Supramolecular Colloids
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Area of Science:

  • * Interdisciplinary research bridging nanotechnology, materials science, and chemistry.
  • * Focus on stereochemistry and self-assembly at the microscale.

Background:

  • * Stereochemistry, the study of 3D molecular arrangements, has traditionally been limited to the nanoscale.
  • * A need exists to extend stereochemical control to larger, micron-sized structures.

Purpose of the Study:

  • * To program the self-assembly of micron-sized colloidal clusters using nanoscale structural information.
  • * To demonstrate precise control over the geometry and chirality of three-dimensional microconstructs.

Main Methods:

  • * Integration of DNA nanotechnology, specifically DNA origami, with colloidal science.
  • * Utilizing the functional flexibility of DNA origami and the rigidity of colloidal particles for programmed self-assembly.

Main Results:

  • * Successful parallel self-assembly of three-dimensional microconstructs.
  • * Achieved highly specific geometry, including control over position and dihedral angles.
  • * Demonstrated control over the chirality of the resulting micro-clusters.

Conclusions:

  • * The study successfully extends stereochemical control from the nanoscale to the microscale.
  • * This novel approach enables the creation of complex, geometrically defined microstructures.
  • * Offers new possibilities for designing and fabricating materials with specific chiral properties at the micron level.