Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isolated Right Atrial Myocarditis Secondary to Listeria Monocytogenes.

JACC. Case reports·2025

Same author

Usability, safety and tolerability of CUE1 vibrotactile device as promising therapeutic approach in orthostatic tremor.

Clinical parkinsonism & related disorders·2025

Same author

Disease activity 4.5 years after starting cladribine: experience in 264 patients with multiple sclerosis.

Therapeutic advances in neurological disorders·2023

Same author

Erythema multiforme-like lesions in a patient with systemic lupus erythematosus progressing to toxic epidermal necrolysis-like lupus.

Clinical and experimental dermatology·2023

Same author

Subcutaneous cladribine to treat multiple sclerosis: experience in 208 patients.

Therapeutic advances in neurological disorders·2022

Same author

Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time: A Systematic Review and Meta-analysis.

JAMA neurology·2019

Same journal

Who I am affects what I do.

Practical neurology·2026

Same journal

Recurrent falls while taking clozapine.

Practical neurology·2026

Same journal

Anti-Ma2 encephalitis: when the examination localises beyond MRI.

Practical neurology·2026

Same journal

Oculopharyngeal muscular dystrophy: diagnosis, management and multisystem care.

Practical neurology·2026

Same journal

Neurological signs of possible diagnostic value in the cognitive clinic: past, present and future.

Practical neurology·2026

Same journal

Longitudinally extensive myelitis in neurosarcoidosis.

Practical neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

Published on: May 11, 2022

Lupus myelopathy.

Dominika D Raciborska¹, Alastair John Noyce^2,3, Dev Pyne⁴

¹Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Practical Neurology

|November 4, 2017

Summary

This summary is machine-generated.

Systemic lupus erythematosus (SLE) can rarely cause myelopathy, a serious spinal cord condition. Early recognition and multidisciplinary care are crucial for managing this rare neurological complication of lupus.

Keywords:

myelopathy neuroimmunology neuropharmacology rheumatology sle

More Related Videos

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes

Published on: April 21, 2023

Related Experiment Videos

Last Updated: Feb 19, 2026

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

A Stably Established Two-Point Injection of Lysophosphatidylcholine-Induced Focal Demyelination Model in Mice

Published on: May 11, 2022

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes

Laminectomy for the Removal of Thoracic Ossification of the Ligamentum Flavum TOLF Using Ultrasonic and Conventional Osteotomes

Published on: April 21, 2023

Area of Science:

Neurology
Rheumatology
Immunology

Background:

Neurological complications are common in systemic lupus erythematosus (SLE).
Myelopathy, a spinal cord dysfunction, is a rare but severe manifestation of SLE.
Central nervous system lupus encompasses various neurological presentations, including less recognized forms like subpial leukomyelopathy.

Observation:

A 35-year-old woman with serological evidence of SLE presented with non-specific symptoms and a respiratory infection.
She rapidly deteriorated, developing a catastrophic spinal cord syndrome.
Initial MRI was normal, but repeat imaging after one month revealed myelitic changes coinciding with progressing encephalopathy.

Findings:

The patient showed a slow response to treatment with cyclophosphamide and corticosteroids.
This case highlights the diverse and sometimes subtle presentations of SLE-related neurological conditions.
The findings underscore the diagnostic challenge posed by lupus-related myelopathy.

Implications:

This case emphasizes the importance of considering lupus myelopathy in patients with SLE and neurological decline.
It highlights the potential for delayed diagnosis due to initially normal imaging.
A multidisciplinary approach is vital for effective management of lupus-related myelopathy.