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Updated: Feb 19, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer

Christopher C Mills1, E A Kolb2, Valerie B Sampson3

  • 1University of Delaware, Newark, Delaware.

Cancer Research
|November 4, 2017
PubMed

Insights

This review explores cell-cycle inhibitors for pediatric cancer, detailing drugs targeting CDK4/CDK6, aurora kinases, Wee1 kinase, KSP, and tubulin. Pediatric-focused development is crucial for advancing treatments for rare childhood cancers.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Cell-cycle and checkpoint regulators are critical in cancer development.
  • Targeting these regulators offers a promising therapeutic strategy for various cancers.
  • Pediatric cancers often differ from adult cancers, necessitating specific drug development approaches.

Purpose of the Study:

  • To review the roles of cell-cycle and checkpoint regulators in pediatric cancer.
  • To discuss the development of specific cell-cycle inhibitors for therapeutic use in children.
  • To highlight the importance of mechanism-based combinations and pediatric-focused drug development.

Main Methods:

  • Review of existing literature on cell-cycle inhibitors.
  • Analysis of drug mechanisms of action, safety, and tolerability in pediatric patients.
  • Discussion of drug development strategies for rare childhood diseases.

Main Results:

  • Pivotal roles of cell-cycle and checkpoint regulators identified.
  • Specific inhibitors targeting CDK4/CDK6 (palbociclib, ribociclib, abemaciclib), aurora kinases (AT9283, MLN8237), Wee1 kinase (MK-1775), KSP (ispinesib), and tubulin (taxanes, vinca alkaloids) discussed.
  • Safety and tolerability data in pediatric patients presented.

Conclusions:

  • Cell-cycle inhibitors show potential for pediatric cancer therapy.
  • Mechanism-based drug combinations are essential for exploiting signaling pathways.
  • Pediatric-focused drug development is critical for advancing treatments for rare childhood diseases.

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