Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.0K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

417
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
417
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

381
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
381
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

19.1K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.1K
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

493
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
493

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of a single bout of exercise on mitochondria-mediated apoptotic signaling in rat cardiac and skeletal muscles.

Journal of exercise rehabilitation·2019
Same author

Metasurface hologram for polarization measurement.

Optics letters·2019
Same author

Echinochrome A Promotes Ex Vivo Expansion of Peripheral Blood-Derived CD34<sup>+</sup> Cells, Potentially through Downregulation of ROS Production and Activation of the Src-Lyn-p110δ Pathway.

Marine drugs·2019
Same author

Novel solute carrier family 26, member 3 mutation in a prenatal recurrent case with congenital chloride diarrhea.

The journal of obstetrics and gynaecology research·2019
Same author

A pure line derived from a self-compatible Chrysanthemum seticuspe mutant as a model strain in the genus Chrysanthemum.

Plant science : an international journal of experimental plant biology·2019
Same author

Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat.

Marine drugs·2019

Related Experiment Video

Updated: Feb 19, 2026

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K

Exercise-Induced Mitochondrial Adaptations in Addressing Heart Failure.

Jubert Marquez1, Jin Han2

  • 1National Research Laboratory for Mitochondrial Signaling, Cardiovascular and Metabolic Disease Center, Department of Health Sciences and Technology, BK21 Project Team, Department of Physiology, College of Medicine, Inje University, Busan, South Korea.

Advances in Experimental Medicine and Biology
|November 4, 2017
PubMed
Summary

Exercise can improve mitochondrial function, which is crucial for treating heart failure. Different exercise types regulate mitochondria, offering therapeutic potential for cardiovascular diseases.

Keywords:
CardiovascularMitochondriaTherapeuticmicroRNA

More Related Videos

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics
07:03

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics

Published on: August 23, 2024

1.6K
Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 19, 2026

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases
08:12

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

2.4K
Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics
07:03

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics

Published on: August 23, 2024

1.6K
Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.7K

Area of Science:

  • Cardiovascular Physiology
  • Mitochondrial Biology
  • Exercise Science

Background:

  • Mitochondria are vital for cellular energy production.
  • Mitochondrial dysfunction is linked to cardiovascular diseases, particularly heart failure.
  • Heart failure involves energy deficits due to impaired mitochondrial bioenergetics.

Purpose of the Study:

  • To explore how various exercise modalities regulate mitochondrial processes.
  • To highlight exercise's role in ameliorating mitochondrial dysfunction in heart failure.
  • To discuss exercise as a therapeutic strategy for heart failure.

Main Methods:

  • Review of existing literature on exercise and mitochondrial function.
  • Analysis of how different exercise types impact mitochondrial dynamics (mass, fusion, fission, mitophagy).
  • Focus on exercise-induced regulation of mitochondrial processes relevant to heart failure.

Main Results:

  • Exercise influences mitochondrial mass, copy number, fusion, fission, and mitophagy.
  • Different exercise protocols elicit distinct regulatory effects on mitochondria.
  • Exercise interventions can improve mitochondrial health and function.

Conclusions:

  • Exercise plays a pivotal role in enhancing mitochondrial state during disease.
  • Exercise-induced mitochondrial regulation offers promising therapeutic strategies for heart failure.
  • Understanding exercise's impact on mitochondria is key for developing novel cardiovascular treatments.