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Updated: Feb 19, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
Published on: September 17, 2017
Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in
Yufei Yang1, ShengQi Xiang, Xiaodan Liu
1College of Chemistry and Molecular Engineering, Beijing, China. wangshenlin@pku.edu.cn.
Abstract:
We report a novel proton-detected MAS solid-state NMR strategy based on 15N-15N proton assisted recoupling to detect the inter-nucleotide NHN hydrogen bonds within the Watson-Crick base pairs of micro-crystallized dimeric RNA and to confirm the kissing-loop structure. This would contribute to advances in the structural determination of RNA using solid-state NMR.
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