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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Estrogen Effects on Wound Healing.

Huann-Cheng Horng1,2,3, Wen-Hsun Chang4,5,6, Chang-Ching Yeh7,8,9

  • 1Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.

International Journal of Molecular Sciences
|November 4, 2017
PubMed
Summary

Estrogen plays a crucial role in skin healing by influencing inflammation and tissue regeneration. Estrogen deficiency impairs wound repair, but estrogen therapy can potentially reverse these negative effects.

Keywords:
estrogenestrogen receptorwound healing

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Area of Science:

  • Dermatology
  • Endocrinology
  • Physiology

Background:

  • Wound healing is a complex physiological process crucial for skin integrity.
  • Disruptions in healing phases (hemostasis, inflammation, proliferation, remodeling) lead to abnormal outcomes.
  • Estrogen significantly impacts skin homeostasis and wound repair mechanisms.

Purpose of the Study:

  • To investigate the role of estrogen in the physiological processes of wound healing.
  • To understand how estrogen deficiency affects skin repair.
  • To explore the therapeutic potential of estrogen in wound healing.

Main Methods:

  • Review of molecular and clinical data on estrogen's effects on skin.
  • Analysis of wound healing phases in the context of estrogen levels.
  • Examination of exogenous estrogen's impact on impaired wound healing.

Main Results:

  • Estrogen deficiency, observed in postmenopausal women, negatively impacts key wound healing stages like inflammation and re-granulation.
  • Exogenous estrogen administration demonstrates potential to ameliorate these detrimental effects.
  • Estrogen influences normal skin homeostasis and contributes to effective wound repair.

Conclusions:

  • Estrogen is vital for effective wound healing, particularly in maintaining proper inflammation and granulation.
  • Estrogen deficiency poses a significant risk for delayed or abnormal wound healing.
  • Estrogen-based therapies represent a promising avenue for enhancing wound healing treatments.