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Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
Published on: May 29, 2017
Development of a disposable kit with fully automatic self-shielding reactor for [18F]FDG synthesis
Seyoung Oh1, Kyungrok Nam2, Kyo Chul Lee3
1Radiopharmaceuticals Production Center, Korea Institute of Radiological & Medical Sciences, 75, Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea; Department of Energy Science, SungKyunKwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, Republic of Korea.
Abstract:
A self-shielding device for the synthesis of radiopharmaceuticals was developed and fabricated in this study. Radiation exposure was minimized by the self-shielding of the kit, installation of the disposable kit in the auxiliary chamber while in a shielded state, and discharge of the kit into a radioactive waste container upon completion of the synthesis process. The developed self-shielding synthesis kit was tested by synthesizing 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in order to verify its performance.
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