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Targeting microRNA to improve diagnostic and therapeutic approaches for malignant mesothelioma

Kimberly A Birnie1, Cecilia M Prêle1,2, Philip J Thompson1

  • 1Institute for Respiratory Health, Centre for Respiratory Health, Harry Perkins Institute of Medical Research, QEII Medical Centre, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.

Oncotarget
|November 5, 2017
PubMed

Insights

Malignant mesothelioma, a cancer linked to asbestos, presents diagnostic and treatment challenges. MicroRNAs (miRNAs) show promise as diagnostic biomarkers and therapeutic targets for this aggressive disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Malignant mesothelioma is an aggressive cancer strongly linked to asbestos exposure, often diagnosed late with limited treatment options.
  • It affects the mesothelial lining, primarily in the pleura, leading to poor survival rates.
  • Increasing exposure from renovations and ongoing asbestos use necessitates new diagnostic and therapeutic strategies.

Purpose of the Study:

  • To review current challenges in mesothelioma diagnosis and treatment.
  • To explore the role of microRNAs (miRNAs) as potential diagnostic and therapeutic targets.
  • To discuss how targeting miRNAs could enhance mesothelioma management.

Main Methods:

  • Literature review focusing on recent advances in mesothelioma research.
  • Analysis of the biological role of microRNAs (miRNAs) in mesothelioma.
  • Evaluation of miRNAs as biomarkers and therapeutic targets.

Main Results:

  • MicroRNAs (miRNAs) play a significant biological role in mesothelioma development.
  • Several miRNAs have been identified as potential therapeutic targets.
  • MiRNAs are stable in bodily fluids and tissues, making them promising biomarkers.

Conclusions:

  • Targeting microRNAs (miRNAs) offers a promising avenue for improving mesothelioma diagnosis.
  • MiRNA-based approaches may enhance prognostic capabilities for mesothelioma patients.
  • MicroRNA-targeted therapies hold potential for more effective mesothelioma treatment.
Keywords:
biomarkersmalignant peritoneal mesotheliomamalignant pleural mesotheliomamicroRNAtherapies

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