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Updated: Feb 19, 2026

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Comparative study on the interaction between 3 CYP2C9 allelic isoforms and benzbromarone by using LC-MS/MS method.

Lingli He1, Chuan Li2, Xuyuan Liu2

  • 1Department of Industrial Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|November 5, 2017
PubMed
Summary

Genetic variations in cytochrome P450 2C9 (CYP2C9) affect how benzbromarone is metabolized. This study developed a method to analyze benzbromarone metabolism by different CYP2C9 variants, revealing significant differences in activity. These findings aid personalized benzbromarone treatment strategies.

Keywords:
BenzbromaroneCYP2C9 allelic isoformsKinetics parametersLC–MS/MS

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