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Liver disease and heart failure: Back and forth

Michele Correale1, Nicola Tarantino2, Rossella Petrucci2

  • 1Ospedali Riuniti University Hospital, Foggia, Italy.

European Journal of Internal Medicine
|November 5, 2017
PubMed

Insights

Physicians must understand the complex heart-liver interactions to effectively treat patients. This review details the mechanisms and clinical implications of this vital cardio-hepatic cross-talk.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Heart and liver diseases frequently coexist and impact each other.
  • Systemic conditions can affect both organs, necessitating a holistic approach.
  • Understanding the heart-liver axis is crucial for optimal patient management.

Purpose of the Study:

  • To review the mechanisms and evidence of the complex interactions between the heart and liver.
  • To summarize clinical presentations, diagnostic markers, and therapeutic considerations.
  • To highlight the reciprocal effects of diseases and treatments on both organs.

Main Methods:

  • Literature review of existing evidence on heart-liver interactions.
  • Discussion of pathophysiology, clinical manifestations, and diagnostic tools.
  • Analysis of drug-induced cardio-hepatotoxicity and post-transplantation effects.

Main Results:

  • Heart failure can lead to congestive and ischemic hepatopathy.
  • Liver diseases, such as cirrhosis, can cause cirrhotic cardiomyopathy.
  • Various conditions and medications can simultaneously affect both heart and liver.
  • Inflammatory mediators and metabolic substrates form a heart-liver axis.

Conclusions:

  • The heart and liver are intricately linked, with bidirectional influences.
  • Recognizing and managing cardio-hepatic interactions is essential for clinical practice.
  • Further research into this axis can improve therapeutic strategies for related diseases.

Keywords:
Cardiovascular diseaseLiver diseaseReview

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