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Association between KIR genes and dust mite sensitization in a Brazilian population
Marcela Caleffi da Costa Lima Caniatti1, Sueli Donizete Borelli1, Ana Lúcia Falavigna Guilherme1
1Department of Basic Health Sciences, Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil.
Background:
Killer cell immunoglobulin-like receptors (KIRs), found on the surface of natural killer (NK) cells, play a key role in controlling the innate response. Such response depends on a series of cellular interactions between these receptors and HLA activating/inhibiting ligands. Atopic diseases have been associated with genes that regulate cytokine production and HLA genes, which may either protect or predispose to hypersensitivity.
Objective:
To verify an association study of KIR genes with sensitization to the following mites: Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Blomia tropicalis.
Methods:
A total of 341 children aged up to 14 years, were classified as mite-sensitive or mite-insensitive after undergoing a skin prick test for immediate allergic reactions. The presence/absence of KIR genes and their human leukocyte antigen (HLA) ligands was determined by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) with the commercial kit LabType™ using Luminex™.
Results:
The frequencies of KIR genes and their respective class I HLA ligands and the frequency of haplotypes were performed in sensitive and insensitive individuals, and no significant differences were found.
Conclusion:
Our results suggest no influence of KIR genes on resistance/susceptibility to sensitization to dust mites.
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