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Updated: Feb 19, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Published on: May 18, 2017
Integrin-linked kinase: A new actor in the ageing process?
Gemma Olmos1, Susana López-Ongil2, Maria Piedad Ruiz Torres1
1Department of System Biology, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; REDinREN (Instituto de Salud Carlos III), Madrid, Spain.
Abstract:
Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors.
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