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Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers.

Andrew J Aguirre1,2,3, William C Hahn1,2,3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.

Cold Spring Harbor Perspectives in Medicine
|November 5, 2017
PubMed
Summary

Targeting KRAS mutations, common in cancer, is difficult. This review explores synthetic lethal vulnerabilities in KRAS-mutant cancers, offering potential new therapeutic strategies.

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