Teaching an old pathway new tricks: Targeting BTK to block NLRP3

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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Sarah E Henrickson1

  • 1Department of Pediatrics, Allergy Immunology Division, the Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA 19104, USA.

Science Immunology
|November 5, 2017
PubMed

Abstract:

A proteomics screen identified BTK as a novel inflammasome regulator and demonstrated that blocking BTK can inhibit inflammasome activity.

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