Teaching an old pathway new tricks: Targeting BTK to block NLRP3
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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
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1Department of Pediatrics, Allergy Immunology Division, the Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA 19104, USA.
Science Immunology
|November 5, 2017
Abstract:
A proteomics screen identified BTK as a novel inflammasome regulator and demonstrated that blocking BTK can inhibit inflammasome activity.

