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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Prebiotics and Bone.

Corrie M Whisner1, Connie M Weaver2

  • 1Arizona State University, School of Nutrition and Health Promotion, Arizona Biomedical Collaborative, 425 N 5th St, Phoenix, AZ, 85004, USA.

Advances in Experimental Medicine and Biology
|November 5, 2017
PubMed
Summary
This summary is machine-generated.

Novel dietary fibers, known as prebiotics, can improve bone health by increasing calcium absorption and bone density. These findings suggest prebiotics may help prevent osteoporosis and maximize bone accretion in children.

Keywords:
AdolescentsBifidobacteriaBone densityCalcium absorptionChildrenFiberMicrobiomeMicrobiotaMineralOsteoporosisPostmenopausal womenPrebioticSkeleton

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Area of Science:

  • Food science
  • Microbiology
  • Nutritional science

Background:

  • Dietary fibers and prebiotics are increasingly synthesized and studied.
  • Prebiotics show promise in improving metabolic conditions, particularly osteoporosis, by modulating the gut microbiome.
  • Existing research indicates prebiotics enhance calcium absorption and bone health in animal models.

Purpose of the Study:

  • To explore the role of prebiotics in bone health.
  • To review current knowledge on prebiotic mechanisms affecting bone metabolism.
  • To identify gaps in research and discuss public health implications.

Main Methods:

  • Literature review of studies on prebiotics, gut microbiota, and bone health.
  • Analysis of data from animal and human studies, including children and postmenopausal women.
  • Discussion of proposed mechanisms, including microbial fermentation and short-chain fatty acid production.

Main Results:

  • Prebiotics increase calcium absorption in the lower gut.
  • Studies in rodents show improved bone mineral density and strength with prebiotic intake.
  • Human data suggest beneficial short- and long-term effects on bone turnover and mineral accretion, especially in growing children and postmenopausal women.

Conclusions:

  • The gut microbiota likely plays a key role in mediating prebiotic effects on bone health.
  • Microbial fermentation of prebiotics increases calcium bioavailability through short-chain fatty acid production and decreased pH.
  • Novel dietary fibers represent a promising, cost-effective strategy for enhancing bone health across the lifespan, potentially preventing osteoporosis.