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Quantitative target proteomics of chromosome 13 human blood plasma proteins
A T Kopylov1, E V Ilgisonis1, O V Tikhonova1
1Orekhovich Institute of Biomedical Chemistry, Moscow, 119121, Russia.
Abstract:
Quantitative proteomic analysis of 50 blood plasma samples of healthy volunteers who underwent a comprehensive medical examination and were found eligible for space flights was performed. As a result of directed mass spectrometric analysis, signals for 128 proteins, which accounted for nearly 40% of the total number of chromosome 13 gene products, were detected. The analysis of interindividual variation of concentrations of chromosome 13 proteins showed the presence of a pool comprising 41 proteins with a low variation (CV < 30%), which can potentially be used as biomarkers.
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