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Updated: Feb 19, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Tetrandrine and cancer - An overview on the molecular approach

Bhagya N1, Chandrashekar K R1

  • 1Department of Applied Botany, Mangalore University, Mangalagangotri, Mangalore 574 199, Karnataka, India.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 5, 2017
PubMed

Insights

Tetrandrine shows promise in cancer treatment by inhibiting cell proliferation and reversing drug resistance. This natural compound modulates key cancer pathways, offering a potential new therapeutic strategy.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Tetrandrine is a known compound with historical applications in treating various diseases.
  • It modulates critical cellular signaling pathways involved in cancer progression.

Purpose of the Study:

  • To review the multifaceted role of tetrandrine in cancer therapy.
  • To explore its mechanisms as a kinase inhibitor, autophagy inducer, and suppressor of RAS-mediated proliferation.

Main Methods:

  • Literature review of in vitro, in vivo, and clinical trial data.
  • Analysis of tetrandrine's effects on signaling molecules, drug resistance, and angiogenesis.

Main Results:

  • Tetrandrine inhibits cell cycle kinases and the rat sarcoma (RAS) pathway.
  • It induces autophagy and caspase pathways, promoting cancer cell death.
  • Tetrandrine reverses multidrug resistance by modulating P-glycoprotein (P-gp) expression.

Conclusions:

  • Tetrandrine exhibits significant anticancer potential through diverse mechanisms.
  • Its ability to overcome drug resistance makes it a promising candidate for cancer treatment, despite bioavailability limitations.
Keywords:
ApoptosisBioavailabilityCyclin dependant kinase inhibitorMulti drug resistanceTetrandrine

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