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Coronary artery stenosis treatment in aging patients with inherited Factor VII deficiency: Where do we stand?

Mariasanta Napolitano1, Sergio Siragusa1

  • 1Haematology Unit, Thrombosis and Hemostasis Reference Regional Center, Università degli studi di Palermo, Italy.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|November 6, 2017
PubMed

Aging with rare bleeding disorders such as factor VII (FVII) deficiency poses several challenges to treatment because of the occurrence of cerebral and cardiovascular age-related comorbidities and high bleeding risks. We report a case of long-term treatment with antiplatelet agents and contemporary prophylaxis of bleeding in a woman affected by severe FVII deficiency diagnosed with symptomatic coronary artery stenosis. Information on the management of antithrombotic treatment in rare bleeding disorders is lacking and mainly limited to anecdotal reports or side effects secondary to replacement therapy. We also briefly reviewed available data on the treatment of arterial thrombosis in FVII deficiency.

Keywords:
Antiplatelet agentsArterial thrombosisBleedingCardiovascular risk factorsFactor VII deficiency

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